Weight, metabolic health, and body composition

Three compounds with different jobs. Semaglutide and Tirzepatide are both GLP-1 protocols — once-weekly injections that act on appetite signaling and the hormones that regulate blood sugar, each formulated with muscle-preserving glycine and B12. Semaglutide acts on the GLP-1 receptor alone; Tirzepatide is a dual agonist that activates both the GLP-1 and GIP receptors, and is often considered a step up. MICC is not a GLP-1 — it is a lipotropic injection of methionine, inositol, choline, and B12 that supports fat metabolism and energy through nutrient pathways, without affecting appetite. Each compound's protocol page goes deeper, and your physician recommends one based on your history and goals.

None of the three is an FDA-approved finished product — compounded medications are not approved by the FDA as finished products. Semaglutide and Tirzepatide are prepared by a US-licensed 503A compounding pharmacy under FDA-regulated quality standards. MICC is prepared by an FDA-registered 503B outsourcing facility under cGMP — current good manufacturing practice — standards, and is subject to FDA inspection. In every case, the protocol is prescribed for an individual patient by a US board-certified physician.

All three protocols are quick injections that ship as ready-to-use solutions — no mixing and no reconstitution. Semaglutide and Tirzepatide are subcutaneous: given just under the skin with an insulin-sized needle, once weekly on the same day. MICC is given once or twice weekly, as your physician directs, and can be injected either subcutaneously or into the muscle. Most men find the routine quick and uncomplicated once they have done it once or twice.

Significant weight loss reduces fat, and without attention to it, some lean muscle as well. Glycine is an amino acid studied for its role in limiting the breakdown of muscle protein during calorie restriction; it is included to support muscle preservation while you lose fat. Vitamin B12 supports nutrient repletion during a period of reduced food intake and may help reduce early nausea. Together, they are why the Semaglutide and Tirzepatide protocols are built around male body composition rather than weight loss alone. MICC also contains B12, as part of its lipotropic formulation.

Often, yes — many men run a metabolic protocol alongside protocols from other categories, including testosterone replacement therapy. One firm rule: GLP-1 protocols are never combined with each other — Semaglutide and Tirzepatide are not taken together, and your physician screens for this. MICC works through nutrient pathways rather than hormone signaling and can sometimes be considered alongside a GLP-1, but that is a clinical decision. Disclose your full medication list during the medical assessment so your physician can account for everything you are taking.

The three protocols run from $79/mo to $299/mo, Free shipping on every order. MICC Lipotropic Injection is $79/mo, Semaglutide Injection is $229/mo, and Tirzepatide Injection is $299/mo. EdgeRx accepts HSA/FSA through Truemed. Physician review and ongoing oversight are included in the subscription — there is no separate physician fee.